Stochastic Model of Acidification, Activation of Hemagglutinin and Escape of Influenza Viruses from an Endosome
نویسندگان
چکیده
1 Applied Mathematics and Computational Biology, Ecole Normale Supérieure, Paris, France, 2 Department of Biology, Molecular Biophysics, IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany, 3 Institute of Chemistry and Biochemistry, Free University Berlin, Berlin, Germany, 4 Newton Institute and Department of Applied Mathematics and Thearetical Physics (DAMTP), Cambridge, United Kingdom
منابع مشابه
Stochastic model of endosomal escape of Influenza virus
Influenza viruses enter a cell via endocytosis after binding to the surface. During the endosomal journey, acidification triggers a conformational change of the virus spike protein hemagglutinin (HA) that results in escape of the viral genome from the endosome to the cytoplasm. A quantitative understanding of the processes involved in HA mediated fusion with the endosome is still missing. We de...
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تاریخ انتشار 2017